plannertotal.blogg.se - What does alt x do

Cirrhotic patients without ongoing liver injury the values may have normal values. Patients with cirrhosis seldom have ALT levels higher than two times normal. Patients with cirrhosis, non-alcoholic steatohepatitis, cholestatic liver disease, fatty liver and hepatic neoplasm typically have slightly raised serum ALT levels (<120 IU/L). In fulminant hepatic necrosis, decreasing ALT may signify a paucity of viable hepatocytes rather than recovery.

Peak ALT levels bear no relationship to prognosis and may fall with worsening of the patients condition.

After peaking, both levels fall rapidly AST faster than ALT. AST is usually higher than ALT and both enzymes peak in the first 24 hours after admission. 90% of cases with ALT >3000 U/L are due to toxic or ischemic injury.

Extremely elevated ALT levels are common in toxic hepatitis and hepatic ischemia secondary to circulatory collapse and heatstroke.

In uncomplicated alcoholic hepatitis, ALT values are almost never >10 times the upper reference limit.

15 to 50% of patients with chronic hepatitis C have persistently normal ALT.

ALT levels fluctuate between normal and abnormal in hepatitis C.

Activity falls slowly, an avery of 10% per day. ALT increases before & peak near onset of jaundice in viral hepatitis.The best ALT discriminant value for recognizing acute hepatic injury is 300 U/L.

X ULN = times upper limit of normal, Protime prolongation is number of seconds above ULN